Clomiphene, 1500mg (25mg/capsule)
Original price was: $79.95.$69.95Current price is: $69.95.
Clomiphene is a synthetic triphenylethylene derivative and a potent Selective Estrogen Receptor Modulator (SERM). It is widely investigated in experimental models for its ability to bind to estrogen receptors in the hypothalamus, thereby influencing the pulsatile release of GnRH and the subsequent secretion of LH and FSH. This compound is a vital tool for researchers examining endocrine signaling and reproductive biology.
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The research utility of Clomiphene Citrate for Sale lies in its unique ability to act as both an estrogen receptor agonist and antagonist, depending on the target tissue and the local estrogenic environment.
Key Areas of Laboratory Investigation:
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HPG Axis Feedback Inhibition: Clomiphene Citrate for Sale is primarily studied for its antagonistic effects at the hypothalamic level. By blocking the negative feedback of circulating estrogens, it “tricks” the regulatory center into perceiving a low-estrogen state, leading to an increase in Gonadotropin-Releasing Hormone (GnRH) pulsatility.
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Gonadotropin Stimulation: Researchers observe the resulting elevation in Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). In male models, this cascade is investigated for its potential to stimulate endogenous testosterone production via Leydig cell activation.
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Tissue-Specific Modulation: Due to its triphenylethylene structure, Clomiphene demonstrates distinct affinity patterns. Studies focus on its anti-estrogenic effects in the hypothalamus and pituitary, contrasted with its varying effects in peripheral tissues like the endometrium or liver.
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Apoptotic Signaling: Recent research has explored Clomiphene’s role in regulating apoptosis and cell proliferation in estrogen-sensitive cancer cell lines, making it a subject of interest in oncology-related molecular studies.
Chemical & Technical Specifications
| Property | Specification |
| Chemical Name | 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine |
| Molecular Formula | $C_{26}H_{28}ClNO$ (Base) / $C_{32}H_{36}ClNO_{8}$ (Citrate) |
| Molecular Weight | 405.96 g/mol (Base) / 598.08 g/mol (Citrate) |
| Purity | ≥98% (HPLC Verified) |
| CAS Number | 911-45-5 (Base) / 50-41-9 (Citrate) |
| Form | Crystalline Powder / Tablets |
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