Enclomiphene (12.5mg/capsule), 60 Capsules
$79.95
Enclomiphene Citrate is the synthetic trans-isomer of clomiphene citrate. Unlike the racemic mixture (which contains both Enclomiphene Citrate and zuclomiphene), Enclomiphene is characterized by its purely antagonistic properties at the estrogen receptor. In laboratory models, it is used to study the upregulation of endogenous gonadotropins without the confounding estrogenic effects of its cis-isomer counterpart.
The research value of Enclomiphene Citrate lies in its ability to selectively modulate the HPG axis. By isolating the trans-isomer, researchers can observe a more potent and predictable endocrine response.
Key Areas of Laboratory Investigation:
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Selective Estrogen Receptor Antagonism: Enclomiphene Citrategen receptors in the hypothalamus and pituitary gland. By blocking the negative feedback of estrogen, it induces an increase in the pulsatile secretion of Gonadotropin-Releasing Hormone (GnRH).
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Gonadotropin Elevation (LH & FSH): Studies focus on the resulting rise in Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). In male experimental models, this cascade is utilized to observe the stimulation of Leydig cells and the subsequent increase in endogenous testosterone production.
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Comparison with Zuclomiphene: Research indicates that while zuclomiphene (the cis-isomer) has a long half-life and demonstrates pro-estrogenic activity, Enclomiphene is cleared more rapidly and acts strictly as an antagonist. This makes it a superior subject for studies requiring a “clean” anti-estrogenic profile.
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Spermatogenesis Models: Beyond hormonal levels, Enclomiphene is investigated for its potential to support or restore spermatogenesis by maintaining high intratesticular testosterone levels via FSH modulation.
Chemical & Technical Specifications
| Property | Specification |
| Chemical Name | (E)-2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine |
| Molecular Formula | $C_{26}H_{28}ClNO$ (Base) |
| Molecular Weight | 405.96 g/mol |
| Purity | ≥99% (HPLC Verified) |
| CAS Number | 15690-57-0 |
| Appearance | White to Off-White Crystalline Powder |
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