Cibinitide ARA-290 16mg KIT (10 vials) 160mg
$855.95
Cibinetide ARA-290 Peptide (ARA-290) is a synthetic 11-amino acid peptide derived from the structure of Erythropoietin (EPO). Engineered specifically for laboratory research, it selectively targets the Innate Repair Receptor (IRR)—a heteromer of the EPO receptor and the $\beta$-common receptor (CD131). ARA-290 is widely investigated for its ability to modulate inflammatory signaling and promote cellular repair without influencing erythropoiesis (red blood cell production).
The primary focus of Cibinetide ARA-290 Peptide research is its “tissue-protective” profile. Because the IRR is only expressed during periods of tissue stress, hypoxia, or injury, ARA-290 serves as a precision tool for studying localized healing responses.
Key Areas of Experimental Focus:
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Neuropathic Signaling: ARA-290 is a leading subject in studies concerning neuropathic pain. Research indicates it may reduce the activation of spinal cord microglia and astrocytes, potentially modulating the pathways that drive chronic pain states.
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Innate Repair Receptor (IRR) Activation: By acting as a specific agonist for the EPOR/CD131 heteroreceptor, Cibinetide ARA-290 Peptide is studied for its ability to initiate anti-apoptotic and anti-inflammatory cascades in damaged cells.
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Metabolic & Vascular Research: Studies in diabetic models investigate ARA-290’s influence on HbA1c levels and lipid profiles, as well as its ability to promote the homing and proliferation of endothelial colony-forming cells (ECFCs).
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Cytokine Regulation: Experimental data suggests that ARA-290 can inhibit the NLRP3 inflammasome and reduce pro-inflammatory cytokines like TNF-$\alpha$, potentially mitigating systemic and localized inflammatory damage.
Chemical & Technical Specifications
| Property | Specification |
| Sequence | Glp-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (Pyroglutamate Helix B) |
| Molecular Formula | $C_{51}H_{84}N_{16}O_{21}$ |
| Molecular Weight | 1257.3 g/mol |
| Purity | ≥99% (HPLC Verified) |
| CAS Number | 1208243-50-8 |
| Form | Lyophilized Powder |
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