SS31 (Elamipretide)

The Mitochondrial Specialist: The Science of SS-31

SS-31, also known as Elamipretide, is a cell-permeable, synthetic tetrapeptide ($D-Arg-2′,6′-Dmt-Lys-Phe-NH2$) that represents a breakthrough in the study of metabolic and degenerative disorders. Unlike broad-spectrum antioxidants that neutralize reactive oxygen species (ROS) in the cytoplasm, SS-31 specifically localizes to the inner mitochondrial membrane (IMM). In laboratory research, it is the primary tool for investigating how the structural stabilization of mitochondrial lipids can reverse cellular dysfunction and boost energy output.

Mechanism of Action:

The unique functionality of SS-31 stems from its high affinity for cardiolipin, a signature phospholipid found exclusively in the IMM. Cardiolipin is essential for anchoring the proteins involved in the Electron Transport Chain (ETC) and maintaining the cristae structure of the mitochondria. Under oxidative stress, cardiolipin undergoes peroxidation, causing the ETC to disassemble and the mitochondria to leak ROS. SS-31 binds to cardiolipin, preventing its oxidation and promoting the reassembly of mitochondrial “supercomplexes.” This leads to:

1. Increased ATP Production: Enhancing oxidative phosphorylation and cellular energy levels.

2. Reduction of ROS: Stopping the production of superoxide at its source within the ETC.

3. Membrane Stabilization: Preventing the opening of the mitochondrial permeability transition pore (mPTP), which triggers cell death.

Technical Specifications:

• Sequence: $D-Arg-2′,6′-Dmt-Lys-Phe-NH2$

• CAS Number: 736992-21-5

• Molecular Formula: $C_{32}H_{49}N_{9}O_{5}$

• Molecular Weight: $639.8 \, g/mol$

• Purity: >99% (HPLC & MS Verified)

• Form: Lyophilized Powder

Applications in Human Research:

SS-31 is a cornerstone for research involving high-energy demand organs and age-related decline:

• Cardiovascular Research: Investigating the peptide’s ability to improve heart muscle function and recovery following ischemic injury.

• Neurodegeneration Studies: Analyzing the role of mitochondrial stabilization in slowing the progression of Alzheimer’s and Parkinson’s markers.

• Kidney Health: Researching its impact on mitochondrial protection in the treatment of acute kidney injury and chronic renal disease.

• Muscle Performance: Studying the restoration of mitochondrial efficiency in aged skeletal muscle to combat sarcopenia and frailty.

The Swiss Chems Scientific Standard

When you look for SS-31 for sale, structural precision is non-negotiable. Because SS-31 relies on its specific charge and sequence to bind to cardiolipin, even minor degradation can render it ineffective. At Swiss Chems, we provide SS-31 that is strictly third-party lab tested via HPLC and Mass Spectrometry to guarantee 99% purity and correct sequence verification.

Our lyophilization process ensures the peptide remains stable during transit and storage. Buy online today from the Official Swiss Chems website and ensure your bioenergetic research is backed by the highest-grade peptides available.