CJC-1295 without DAC 2 mg
CJC-1295 without DAC (also known as Modified GRF 1-29) is a synthetic 29-amino acid peptide analog of endogenous Growth Hormone Releasing Hormone (GHRH). By omitting the Drug Affinity Complex (DAC), this variant is engineered for a shorter half-life, making it an ideal tool for researchers studying acute pulsatile signaling and rapid receptor turnover in laboratory models.
The “No DAC” variant is often preferred in studies that require precise control over the timing and duration of receptor activation. It is a tetrasubstituted analog of Sermorelin, modified at positions 2, 8, 15, and 27 to increase resistance to enzymatic cleavage while maintaining a physiological clearance rate.
Key Areas of Laboratory Investigation:
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Pulsatile Signaling Models: Unlike the DAC version, which provides a “bleed” of signaling, CJC-1295 No DAC is used to study the natural pulsatile release of growth hormone, mimicking the body’s circadian rhythms in experimental animals.
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Rapid Pharmacokinetics: Without the DAC modification, this compound demonstrates a half-life of approximately 30 minutes. This allows for specific types of acute laboratory studies where researchers need the compound to clear the system quickly between testing intervals.
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Selective Receptor Binding: In vitro studies show high selectivity for the GHRH receptor (GHRHR). Researchers observe how this binding influences the intracellular cAMP (cyclic Adenosine Monophosphate) pathways.
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Pituitary Sensitivity: This peptide is frequently utilized to assess the sensitivity and functional capacity of the anterior pituitary gland in various disease or aging models.
Chemical & Technical Specifications
| Property | Specification |
| Sequence | Tyr-d-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Ile-Ser-Arg-NH2 |
| Molecular Formula | $C_{152}H_{252}N_{44}O_{42}$ |
| Modification | None (Free peptide) |
| Purity | ≥99% (HPLC Verified) |
| Form | Lyophilized Powder |
| Molecular Weight | 3367.9 g/mol |
Research Comparison: CJC-1295 No DAC vs. DAC
| Feature | CJC-1295 No DAC | CJC-1295 with DAC |
| Half-Life | ~30 Minutes | ~6–8 Days |
| Mechanism | Acute/Pulsatile | Sustained/Basal |
| Albumin Binding | Low | High (via DAC) |
| Research Goal | Precise, timed pulses | Long-term systemic exposure |
| CJC-1295 without DAC 2 mg |
Vial ,10 vial |
|---|
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