Trevogrumab 1mg (1 vial)

The Myostatin Modulator: The Science of Trevogrumab

Trevogrumab (REGN03) is a fully human monoclonal antibody (mAb) designed to bind to and neutralize Growth Differentiation Factor 8 (GDF-8), commonly known as Myostatin. Myostatin is a member of the Transforming Growth Factor-beta (TGF-$\beta$) superfamily and acts as a potent negative regulator of skeletal muscle mass. In laboratory research, Trevogrumab is utilized to study the physiological effects of removing this “molecular brake,” providing a robust model for investigating muscle hypertrophy and the reversal of muscle wasting.

Mechanism of Action:

Trevogrumab operates by selectively binding to the circulating Myostatin protein with high affinity. This binding prevents Myostatin from interacting with its primary receptor, the Activin Receptor Type IIB (ActRIIB), on the surface of muscle cells. Under normal conditions, Myostatin-ActRIIB signaling activates the Smad2/3 pathway, which inhibits the differentiation of myoblasts and protein synthesis. By neutralizing Myostatin, Trevogrumab:

1. Increases Myogenesis: Promotes the proliferation and differentiation of satellite cells into new muscle fibers.

2. Enhances Protein Synthesis: Shifts the cellular balance toward anabolism by downregulating the ubiquitin-proteasome pathway.

3. Reduces Muscle Atrophy Signaling: Inhibits the expression of atrogenes, which are typically responsible for muscle breakdown during periods of inactivity or disease.

Technical Specifications:

• Target: Growth Differentiation Factor 8 (GDF-8) / Myostatin

• Class: Monoclonal Antibody (IgG4)

• CAS Number: 1318075-81-6

• Molecular Weight: Approximately $145 \, kDa$

• Purity: >99% (SEC-HPLC Verified)

• Form: Lyophilized Powder

Applications in Human Research:

Trevogrumab is a core subject in studies targeting the preservation and enhancement of physical function:

• Sarcopenia and Aging: Investigating the antibody’s ability to restore muscle mass and strength in elderly models suffering from age-related muscle loss.

• Muscular Dystrophy Research: Studies focus on whether neutralizing Myostatin can compensate for the lack of dystrophin and maintain contractile function.

• Metabolic Health: Researching the link between increased skeletal muscle mass and improved systemic glucose disposal and insulin sensitivity.

• Orthopedic Recovery: Analyzing the role of Myostatin inhibition in accelerating recovery following major joint surgery or prolonged immobilization.

The Swiss Chems Scientific Standard

When you look for Trevogrumab for sale, the structural integrity of the monoclonal antibody is paramount. mAbs are complex, large molecules that require precise manufacturing and stabilization to prevent aggregation or loss of binding affinity. At Swiss Chems, we guarantee that our Trevogrumab is strictly third-party lab tested via Size-Exclusion Chromatography (SEC-HPLC) to confirm purity and molecular weight.

Our lyophilization process ensures the antibody remains stable during transit and storage. Buy online today from the Official Swiss Chems website and ensure your musculoskeletal research is backed by the highest-grade monoclonal antibodies available.