MOTS-C 10mg

The Mitochondrial Frontier: Understanding MOTS-c

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a groundbreaking mitochondrial-derived peptide (MDP). Unlike most peptides encoded in the cell nucleus, MOTS-c is unique because it is encoded within the mitochondrial genome itself. This “mitochondrial signaling” molecule acts as a critical bridge between the mitochondria and the nucleus, coordinating cellular metabolic regulation and adaptive stress responses. In the realm of longevity and metabolic research, MOTS-c is considered one of the most promising compounds for its ability to regulate systemic energy homeostasis.

Mechanism of Action:

MOTS-c functions primarily as a metabolic regulator through the activation of the AMPK (AMP-activated protein kinase) pathway. AMPK is the body’s “master metabolic switch,” responsible for monitoring energy levels. By activating this pathway, MOTS-c promotes glucose uptake in skeletal muscle and enhances fatty acid oxidation. Furthermore, research indicates that MOTS-c can translocate to the nucleus during metabolic stress to regulate gene expression, particularly those genes involved in antioxidant responses and glucose metabolism. While it demonstrates high stability in circulation, it possesses a transient bioactivity profile due to rapid proteolytic processing and renal clearance, allowing for precise research into acute metabolic shifts.

Technical Specifications:

• Amino Acid Sequence: $Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Ala-Leu-Ser-Ile-Asn-Ala$

• Molecular Formula: $C_{101}H_{152}N_{28}O_{22}S_{2}$

• Molecular Weight: $2174.6 \, g/mol$

• Purity: >99% (HPLC & MS Verified)

• Form: Lyophilized Powder

Applications in Human Research:

The potential for MOTS-c in human research models is vast, particularly in the fields of aging and performance:

• Metabolic Flexibility: Studies focus on MOTS-c’s ability to reverse insulin resistance and prevent diet-induced obesity by shifting the body’s energy preference toward fat oxidation.

• Longevity & Anti-Aging: Investigating the peptide’s role in maintaining mitochondrial function, which typically declines with age, leading to systemic vitality.

• Physical Performance: Often researched as an “exercise mimetic,” studies analyze how MOTS-c enhances physical capacity and heat production in muscle tissue.

• Osteoporosis Research: Emerging data suggests MOTS-c may play a role in promoting osteoblast differentiation, providing a pathway for bone health studies.

The Swiss Chems Quality Standard

When you look for MOTS-c for sale, you are investing in the future of metabolic science. At Swiss Chems, we understand that mitochondrial peptides require extreme precision during synthesis to maintain biological activity. Our MOTS-c is strictly third-party lab tested for purity and correct amino acid sequencing, ensuring no truncated or inactive fragments interfere with your findings.

Buy online today from the Official Swiss Chems website to ensure your lab is equipped with the purest MOTS-c available. We provide the stability, transparency, and clinical-grade quality necessary to take your research to the next level.