Dihydromyricetin (DHM) – Powder, 50 grams
$29.99
Dihydromyricetin (DHM) Powder is a synthetic or plant-derived flavonoid investigated for its potent antioxidant properties and its unique interactions with the Central Nervous System (CNS). It is widely studied in experimental models for its ability to modulate GABAa receptors and its influence on metabolic pathways, particularly those involving ethanol degradation and hepatic lipid regulation.
Dihydromyricetin (DHM) Powder research utility stems from its ability to cross the blood-brain barrier and interact with specific receptor sites, as well as its systemic influence on oxidative stress markers.
Key Areas of Laboratory Investigation:
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GABAa Receptor Modulation: Dihydromyricetin (DHM) Powder is a primary subject in neuropharmacology for its role as a selective negative modulator of the GABAa receptor’s benzodiazepine site. Researchers study its ability to counteract the effects of ethanol and its potential in investigating alcohol-use disorder models.
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Ethanol Metabolism: Studies focus on Dihydromyricetin (DHM) Powder ability to upregulate the activity of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in the liver. This makes it a critical tool for exploring the acceleration of toxin clearance in metabolic research.
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Antioxidant Signaling: Laboratory research demonstrates that DHM activates the AMPK pathway and increases the expression of endogenous antioxidants like Superoxide Dismutase (SOD) and Glutathione (GSH), protecting cells from oxidative damage.
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Hepatoprotective Activity: DHM is examined for its ability to reduce pro-inflammatory cytokines such as TNF-$\alpha$ and IL-6, and its potential to inhibit lipid accumulation in hepatocytes (liver cells) in fatty-liver models.
Chemical & Technical Specifications
| Property | Specification |
| Chemical Name | (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one |
| Molecular Formula | $C_{15}H_{12}O_{8}$ |
| Molecular Weight | 320.25 g/mol |
| Purity | ≥98% (HPLC Verified) |
| CAS Number | 27200-12-0 |
| Appearance | Fine White to Light Yellow Powder |
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