RU58841 – Powder, 5 grams

Targeted Androgen Inhibition: The Science of RU58841

RU58841 (also known as PSK-3841) is a non-steroidal Androgen Receptor (AR) antagonist that has become a focal point in dermatological and hair follicle research. Unlike systemic anti-androgens that lower total testosterone or DHT levels, RU58841 is designed to compete directly with endogenous androgens at the receptor site. In laboratory models, it demonstrates an exceptional affinity for the androgen receptor, allowing researchers to study the modulation of receptor-mediated transcriptional activity without interfering with the subject’s systemic hormonal profile.

Mechanism of Action:

RU58841 operates through competitive inhibition. It possesses a molecular structure that allows it to bind to the androgen receptor with a higher affinity than Dihydrotestosterone (DHT) or Testosterone. Once bound, it acts as a “silent” antagonist, meaning it occupies the receptor without activating the signaling pathways that lead to follicle miniaturization or sebaceous gland overactivity. A key characteristic of RU58841 is its metabolic instability when entering the bloodstream; it undergoes rapid hydrolytic degradation and enzymatic oxidation into inactive metabolites. This property makes it a primary candidate for studying localized effects while minimizing systemic exposure.

Technical Specifications:

• Chemical Name: 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile

• CAS Number: 154992-24-2

• Molecular Formula: $C_{17}H_{18}F_{3}N_{3}O_{3}$

• Molecular Weight: $369.34 \, g/mol$

• Purity: >99% (HPLC Verified)

• Form: Raw Powder / Topical Solution

Applications in Human Research:

RU58841 is extensively utilized in studies targeting androgen-sensitive tissues:

• Follicle Protection Research: Investigating the compound’s ability to prevent DHT-induced miniaturization of hair follicles in models of androgenetic alopecia.

• Dermatological Signaling: Researching the modulation of sebum production and its potential role in treating androgen-mediated skin conditions like acne.

• Localized Receptor Mapping: Using the compound to identify and block androgen receptors in specific tissue samples without affecting the HPTA axis.

• Comparison Studies: Benchmarking the efficacy of non-steroidal antagonists against 5-alpha reductase inhibitors like Finasteride.

The Swiss Chems Scientific Standard

When you look for RU58841 for sale, stability and purity are the most critical factors. Because RU58841 is sensitive to environmental degradation, Swiss Chems ensures that our product is handled under strict laboratory conditions to maintain its molecular integrity. Every batch is third-party lab tested via HPLC to guarantee that the compound is free from unreacted intermediates and heavy metals.

Choose the most trusted name in research chemicals. Buy online today from the Official Swiss Chems website and secure the high-purity materials necessary for accurate, reproducible dermatological research.