TB-500 500mg (1vial)

The Molecular Architect: The Science of TB-500

TB-500 is a synthetic peptide analog of Thymosin Beta-4 (T$\beta$4), a ubiquitous regenerative protein found in high concentrations in blood platelets and wound fluid. It is specifically designed to isolate and utilize the active actin-binding domain of the parent molecule. In research applications, TB-500 is highly regarded for its low molecular weight, which grants it superior tissue penetration compared to larger proteins, allowing it to migrate across long distances in the body to localize at sites of experimental injury.

Mechanism of Action:

TB-500 operates through its high-affinity interaction with G-actin (globular actin). By binding to G-actin, the peptide prevents its polymerization into F-actin (filamentous actin), effectively maintaining a pool of actin monomers available for rapid cytoskeletal reorganization. This modulation of cytoskeletal dynamics is a critical driver for:

1. Cellular Migration: Facilitating the movement of endothelial and progenitor cells to damaged tissues.

2. Angiogenesis: Promoting the formation of new micro-vasculature to restore nutrient delivery to ischemic areas.

3. Molecular Signaling: Influencing various growth factors and matrix metalloproteinases that regulate the extracellular environment.

The peptide undergoes steady enzymatic hydrolysis, with primary metabolism occurring through proteolytic degradation. Metabolic clearance is primarily achieved via renal excretion, ensuring a predictable pharmacokinetic profile in laboratory settings.

Technical Specifications:

• Sequence: $Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser$

• CAS Number: 77591-33-4

• Molecular Formula: $C_{212}H_{350}N_{56}O_{78}S_{1}$

• Molecular Weight: $4963.5 \, g/mol$

• Purity: >99% (HPLC & MS Verified)

• Form: Lyophilized Powder

Applications in Human Research:

The versatile structural and signaling profile of TB-500 makes it a focal point for various regenerative studies:

• Connective Tissue Repair: Investigating the peptide’s role in the repair of tendons, ligaments, and muscle fibers following mechanical stress.

• Neovascularization: Studies focus on its ability to stimulate blood vessel growth in tissues with poor circulation.

• Inflammatory Response: Analyzing the modulation of pro-inflammatory cytokines during the acute phase of tissue damage.

• Dermatological Recovery: Researching the acceleration of epithelial migration to close dermal wounds and minimize fibrosis.

The Swiss Chems Scientific Standard

When you look for TB-500 for sale, the integrity of the peptide sequence is paramount to ensuring its actin-binding affinity. Many suppliers provide peptides with truncated sequences or high levels of salt contamination. At Swiss Chems, we guarantee that our TB-500 is strictly third-party lab tested via HPLC and Mass Spectrometry to confirm absolute purity and correct molecular weight.

Our lyophilization process ensures maximum stability and shelf-life for your laboratory. Buy online today from the Official Swiss Chems website and secure the high-purity peptides required for advanced structural and regenerative research.